7#``(p @xV v* * Lesson 6 Knowledge Mapping Teacher's Guide

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Pattern Matching

Time

This exercise takes approximately 6 hours.

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Objectives

Once you have completed this knowledge mapping exercise, you should be able to:
1.Have a deeper understanding of organic molecules.
2.Be able to identify masked concepts based upon their relations to other concepts.
3.Know how to organize and construct a semantic network.
4.Be able to name the four major classes of organic molecules and to describe their key features.
5.Appreciate that in biology small differences in structure lead to large differences in function -- as in, for example, the structures of testosterone and estradiol, which produce male or female secondary sex characteristics.

Download the net, 1.6d Pattern Matching Exercise, which contains all the concepts and relations described in 1.6c. (below) Students can use the components in this net to construct their network describing organic molecules.

Organic molecules provide an excellent domain in which to practice knowledge organization skills, and the knowledge organization efforts of your students should significantly improve their understanding of the biology.

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Exercise 1

Understanding the Links

1. You can do this exercise alone or in groups of three or four students each. Use lined paper for your work and have one or more biology texts on hand for reference.
2. Your primary goal is to put all your ideas about organic molecules together in a coherent and well-organized way. You need to be clear about the relations between various ideas, and as you clarify your understanding of these linkages, you will find yourself developing a better understanding of the entire topic.
3. Your secondary goal is to systematically build your knowledge organization skills.
To Do 4. You will begin by working your ideas out with paper and pencil. Table 1 shows all the relations we used to construct a network of ideas about organic molecules. Thoughtfully define each relation and give an example of how to use it. Compare your definitions with those created by other members of your group and resolve any differences.

Table 1. Relations Useful for Describing Organic Molecules

ASYMMETRIC RELATIONS
produces produced by
has type type of
has characteristic characteristic of
has subunit subunit of
has example example of
provides energy transport with provides energy transport in
includes included in
has component component of
definition of has definition
has part part of
provides provided by
gains phosphate to form loses phosphate to form
site of occurs at site
input to has input
has kind kind of
SYMMETRIC RELATIONS
same as  
contrasts with  
pairs with  
converted into  
combines with  
in dynamic equilibrium with  

In Table 1b below, we provide a definition and example for each relation, and in some cases also offer a synonym or closely related relation. We also identify more and less general relations of similar types.

Table 1b. Examples of Relations Using Asymmetric Relations

ASYMMETRIC
produces / produced by - link between a reaction and a physical product or energy created by that reaction; e.g., DNA synthesis produces DNA; similar: has output / output of
has type / type of - link between a class or category of things and a thing that is a member of that class or category; e.g., organic molecule has type protein; similar: includes / included in, set has member / member of set
has characteristic / characteristic of - link between an event or thing and an attribute of that event or thing; e.g., testosterone has characteristic non-polar; similar: has attribute / attribute of-/td>
has subunit / subunit of - in this net, a link between a macromolecule and its key building block(s); e.g., nucleotide has subunit nitrogenous base, 5-carbon sugar, phosphate; similar: has part / part of; has component / component of-
has example / example of -- link between a class or category of things and a specific example of that class or category; e.g., amino acid has example glycine; similar: has type / type of/td>
provides energy transport with / provides energy transport in - in this net, link between molecule used for energy transport and type of organism; e.g., animal provides energy with glucose
includes / included in - broader than has type, could have the same meaning or could be used to mean has part / part of or to stand for any other inclusion relation; e.g., organic molecule includes macromolecule
definition of / has definition - link between a word or phrase and its definitive description; e.g., DNA has definition double strand of ds deoxyribonucleic acid composed of A,T,G, and C.
has part / part of - link between physical part and a larger structure in which it is contained; e.g., amino acid has part carboxyl group; similar: has component / component of
provides / provided by - in this net, links type of organic molecule to its food source; e.g., meat provides protein; similar: supplies / supplied by
gains phosphate to form / loses phosphate to form - link between nucleoside monophosphate and nucleoside diphosphate, or between nucleoside diphosphate and nucleoside triphosphate; e.g., ATP loses phosphate to form ADP
site of / occurs at site - link between a reaction or event and the location in which that reaction or event occurs; e.g., DNA synthesis occurs at site nucleus.
input to / has input - links a substance or entity that is used in a reaction to that reaction; e.g., DNA synthesis has input energy; similar to: has substrate / substrate in

Table 1c. Examples of Relations Using Symmetric Relations

SYMMETRIC
same as - - links two synonyms or identical terms or phrases; e.g., DNA same as deoxyribonucleic acid; similar: similar to
contrasts with - - links two opposites or near-opposites or clearly dissimilars; e.g., DNA contrasts with RNA
pairs with - in this net, refers to the bonding between nitrogenous bases in nucleic acids; e.g., adenine pairs with thymine, adenine pairs with uracil
converted into - links two substances, one of which has been created from the other by some sort of modification or transformation; e.g., ATP converted into ADP; in this net, used interchangeably with gains phosphate to form / loses phosphate to form, although converted into has a more general meaning
combines with - links two components that can be combined in a combination reaction; e.g., nucleoside combines with phosphate; similar: reacts with (the latter is more general, however)
in dynamic equilibrium with - in this net, links two forms of a molecule that spontaneously convert from one to the other; e.g., straight chain sugar in dynamic equilibrium with ring sugar; could use the more general converted into

There is little standardization regarding the terms preferred for describing particular relationships. We have found the general form, has ___ / ___of, is conveniently short and works well for many relations. Being consistent with this style when possible helps in retrieval and application of links.

There is a constant tension between parsimony (using as few relations as possible) and specificity (using more relations to provide more detail about various relationships). In this net, we take an intermediate approach, using several relations that have similar meanings yet keeping the overall number of relations small.

For the sections that follow, download 1.6 Pattern Matching Net. which is a completed network showing how we have put these ideas (and more) together. This net provides a useful exemplar and guide, but it should not be considered THE right answer. It is important to understand that we all think in different ways. There are multiple correct ways, and multiple incorrect ways, to put these ideas together. You will have to use your judgment, reviewing each net as if it were an essay. This means that you will need to have a fairly good understanding of the topic.

We typically review a net by looking at the About Net dialog first to see its overall size and the ratio of instances to concepts (which ideally should be close to 1.5 in a biology net). Then we examine the quality of the relations, which will be relevant here only if the students add new relations. Then we review concepts with three or more connections, looking at the accuracy of each instance and the completeness and correctness of the concept description. Using printouts of the nets permits you to make comments that you can pass back to the students.

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Exercise 2

Describing Proteins

To Do 1. Table 2 summarizes key ideas about proteins. Organize these ideas on paper.

Table 2. Key Ideas about Proteins

PROTEINS
IdeasIdeas Descriptors/Parts
alanine
amine group
amino acid
arginine
asparagine
aspartic acid
carboxyl group
cysteine
glutamic acid
glutamine
glycine
histidine
isoleucine
leucine
lysine
methionine
-N-C-C- backbone
phenylalanine
proline
protein
serine
threonine
tryptophan
tyrosine
valine
carbon
carrier protein
CHNOS
complex folding
enzyme
hydrogen
length 15 - 4000 aa
linear chain of aa
nitrogen
oxygen
structural protein
sulfur
toxin

* Basic building blocks are bold and key macromolecules are in italics.

2. If you already know how to do this, go ahead without our help. Otherwise, follow our suggestions below. Feel free to add additional concepts and descriptors as you wish. Try not to add any new relations. There are two main ideas to describe here, protein and amino acid.

Table 3. Describing a Protein

Relation# of Related Concepts
has subunitone idea
has part6 descriptors
has characteristic3 descriptors
has type5 descriptors

Table 4. Describing an Amino Acid

Relation# of Related Concepts
has part3 ideas
has kind20 ideas

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Exercise 3

Describing Carbohydrates

To Do 1. Key ideas about carbohydrates are summarized in Table 5. Use the same principles as above for describing carbohydrates, using the relations systematically and consistently. There are fewer ideas here, but the descriptions may be richer. Add any general information that you know about each idea.

Table 5. Key Ideas about Carbohydrates*

Ideas Descriptors/Parts
carbohydrate
cellulose
disaccharide
fructose
glucose
glycogen
monosaccharide
polysaccharide
ribose
saccharide
starch
sucrose
sugar
table sugar
3-carbon sugar
5-carbon sugar
6-carbon sugar
carbon
CHO
complex hydrocarbons
cross linked
easily digestible
hydrogen
indigestible by most
insoluble
long chain hydrocarbons
long chain sugars
oxygen
ring structure sugar
straight chain sugar
two glucose molecules

* Basic building blocks are bold and key macromolecules are in italics.

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Exercise 4

Describing Lipids

To Do 1. Organize your knowledge about lipids in the same manner, using all the concepts in Table 6 and any additional knowledge that you are able to bring in (where are lipids found?, what do they do in the body?, etc.).

Table 6. Key Ideas for Describing Lipids*

Ideas Ideas Descriptors/Parts
cholesterol
estradiol
fat
fatty acid
glycerol
hormone
lipid
oil
oleic acid
palmitic acid
phosphate head
phospholipid
progesterone
stearic acid
steroid
testosterone
wax
1/more double C=C bond
2/more double C=C bonds
all C-C bonds are single
carbon
CHO
hydrogen
mono-unsaturated
multi-ring structures
one double C=C bond
oxygen
poly-unsaturated
saturated
solid at room temp
unsaturated

* Basic building blocks are bold and key macromolecules are in italics.

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Exercise 5

Describing Nucleic Acids

1. Because nucleic acids are composed of subunits that have three different parts, and because those parts differ in RNA and DNA, and because the subunits add and lose phosphates, your description of nucleic acids will be more complex than those of the other three groups of organic molecules.
To Do 2. Put these ideas together as you have done above. We'll give you a few hints. You can skip them if you feel you don't need them.
3. Begin with identity using the 'same as' relation. For example, 'ATP' is the same as 'adenosine triphosphate' and 'DNA' is the same as 'deoxyribonucleic acid'. Match up all abbreviations in this way.

Table 7. Key Ideas for Describing Nucleic Acids*

Ideas Ideas Descriptors/Parts
adenine
adenosine diphosphate
adenosine monophosphate
adenosine triphosphate
ATP
C-G base pair
A-T base pair
A-U base pair
CTP
cytidine diphosphate
cytidine monophosphate
cytidine triphosphate
cytosine
deoxyribonucleic acid
deoxyribose
diphosphate
DNA
DNA nitrogenous base
DNA nucleotide
GTP
guanidine diphosphate
guanine
guanodine monophosphate
guanodine triphosphate
nitrogenous base
nucleic acid
nucleic acid synthesis
nucleoside
nucleoside diphosphate
nucleoside monophosphate
nucleoside triphosphate
nucleotide
ribose
guanosine diphosphate
ribonucleic acid
RNA
RNA nucleotide
RNA nitrogenous base
phosphate
thymidine diphosphate
thymidine monophosphate
thymidine triphosphate
thymine
TTP
uracil
uridine diphosphate
uridine monophosphate
uridine triphosphate
UTP
-H on carbon 2
-OH on carbon 2
carbon
CHNOP
high energy bonds
hydrogen
nitrogen
oxygen
phosphorus

* Basic building blocks are bold and key macromolecules are in italics.

5. Then do the conversions. For example, 'adenosine triphosphate' can be converted into 'adenosine diphosphate' which can be converted into 'adenosine monophosphate'. All five nitrogenous bases will have similar conversions.
6. Think about the whole/part relations. 'DNA' and 'RNA' each has subunit 'nucleotide'. Each 'nucleotide' pas part 'nucleoside' and 'phosphate'. Each 'nucleoside' has part 'nitrogenous base' and 'sugar' ('ribose' or 'deoxyribose'). This set of relations can be developed for each of the five bases (A, T, G, C, U).
7. Think about the type relations. There are two types of nucleic acids, five basic types of nucleotides, five types of nucleosides and five types of nitrogenous bases. Make all these connections.
8. Nucleic acids are composed of what atoms? Work out these relations.
9. Look at the descriptors. What concepts do they best describe?

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Exercise 6

Big Ideas

1. Finally, think about the big ideas you will use to tie the entire network together (Table 8). When organizing your knowledge, you want to 'sew your ideas up the hierarchy' to one encompassing concept when possible. In this case, each of the four classes of molecules we have described is a type of 'organic molecule'. Work out the best linkages for each of the big ideas and any others you want to add.

Table 8. Some Big Ideas

BIG IDEAS
animal
atom
biochemical reactions
homeostasis
inorganic molecule
liquid
living thing
macromolecule
matter
metabolism
molecule
organic molecule
plant
amphipathic
carbon-based
CHNOPS
contains 2/more atoms
covalently bonded
non-polar
one end non-polar
one end polar
soluble
water-hating

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Exercise 7

Constructing Your Network of Ideas

To Do 1. You have now completed your pre-planning. Your teacher will give you a semantic network called '1.6c Pattern Matching Exercise' which contains all the concepts and relations named in the tables above. Your task is to put these together by creating instances. In doing so, use the Down arrow for the Relation Dialog in the create an Instance dialog to select the desired relation ray, and let name completion help you enter each concept name. Doing this is work-efficient and will save many errors and confusions. Use all the concepts in the net, describe each idea well, use relations in a consistent and systematic manner, and try to optimize your net coherency and organization.

Two big advantages of hierarchical organizations are ease of retrieval (you only need to recall the top concept and then can flow down the hierarchy) and simplification of learning due to inherited traits (if you know that a dining room chair, an armchair, a dentist's chair, etc. are all chairs, then you know a great deal about them even if you have never seen one). Encourage your students to tie things together very well at the tops of the hierarchies. Ask them to review their nets several times to see if there are additional links to be made. Likewise, reactions and flows should be complete. The polishing and refining of a net is an important step.

Try to look over your students' shoulders and give them feedback and suggestions at several points during net construction. Encourage the students to look at one another's nets as well to see alternative ways of organizing these ideas. Ask your students to check and make sure they have no concepts with zero connections (by looking at Concepts - By # of Instances (Display menu), at the bottom end of the list.

2. When done, submit your net to the teacher for review. Your teacher may want you to print it out as follows:

a. About Net. Select Print from the File menu and you will get the Print Dialog Box as shown in Figure 1. Click once on the radial (round) button beside About Net in the first column. Click on Print.

Figure 1. Print Dialog Box

b. Concepts, Alphabetical. Select Print from the File menu. Select Concepts and Text. The computer will automatically select Alphabetical and All. Select attached items, Header, Numbering, and Statistics. Click on the Print button.

c. Relations, Creation Order. Select Print from the File menu. Select Relations, Text, Creation, and All. Select attached items, Header, Numbering, and Statistics. Click on the Print button.

d. Concepts, Graphically. Select Print from the File menu. Select Concepts, Graphic, Compact Screen, Creation, and Concepts with 3 or more instances (not All). Select attached items, Header, Numbering, and Statistics. Click on six frames per page. Click on the Print button.

3. Staple the pages together in the order given, put the names of your group members on the front, and give them to your teacher for review and comment.
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